Former Orange prize winner Ann Patchett is in the running for the award for fiction written by women for the second time.
Shortlisted alongside six novels, State of Wonder is set in the Amazonian rainforest, and is an epic tale of science and memories based around a drug that could change women's lives forever. Patchett won the prize 10 years ago for Bel Canto.
Patchett was amongst three American writers named: Patchett, Madeline Miller and Cynthia Ozick, who, at 84, is the oldest writer to have been shortlisted. There was one Briton, Georgina Harding, an Irish writer, Anne Enright, and Canadian Esi Edugyan.
Joanna Trollope, chair of the judging panel, said: "This is a shortlist of remarkable quality and variety. It includes six distinctive voices and subjects, four nationalities and an age range of close on half a century. It is a privilege to present it.
"My only regret is that the rules of the prize don't permit a longer shortlist. However, I am confident that the 14 novels we had to leave out will make their own well-deserved way."
Copyright Speakers Corner 2016