The former Something for the Weekend hosts will move to the channel to host a new show called Sunday Brunch.
Something for the Weekend was cancelled earlier this year after a run of almost six years on the BBC, but former Something for the Weekend production company Princess Productions will make Sunday Brunch for Channel 4.
"We're chuffed to be joining Channel 4," Tim and Simone said in a joint statement. "We have a great laugh working together and we're very pleased we can continue that in our new home."
Channel 4's Dominic Bird, who commissioned the programme, added: "Simon and Tim have brilliant on-screen chemistry and their partnership will be at the heart of Sunday Brunch. They're a great fit for Channel 4 and we can't wait to get going on the new show."
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