Comedian Bill Bailey will be replaced by a series of guest captains when comedy quiz Never Mind the Buzzcocks returns to BBC Two on 2 October.
Bailey is bowing out after "11 series selflessly, heroically and hilariously" leading one of the show's two teams, said its producer Talkback Thames.
Host Simon Amstell and team captain Phill Jupitus will appear as normal.
Never Mind the Buzzcocks first aired on the BBC in 1996, with Mark Lamarr asking the questions and Jupitus and Sean Hughes answering them.
Bailey, an accomplished musician who is leaving the show due to unspecified "other commitments", took over from Sean Hughes in 2002.
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